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| 3D cell culture ： ウィキペディア英語版 |
3D cell culture
A 3D cell culture is an artificially-created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. This is an improvement over the previous method of growing cells in 2D (on a petri dish) because the 3D model more accurately models the in vivo cells.
These three-dimensional cultures are usually grown in bioreactors, small capsules in which the cells can grow into spheroids, or 3D cell colonies. Approximately 300 spheroids are usually cultured per bioreactor.〔
== Background ==
Early studies in the 80’s, led by Mina Bissell from the Lawrence Berkeley National Laboratory, highlighted the importance of 3D techniques for creating accurate in vitro culturing models. This work focused on the importance of the extracellular matrix and the ability of cultures in artificial 3D matrices to produce physiologically relevant multicellular structures, such as acinar structures in healthy and cancerous breast tissue models. These techniques have proven to be very important for in vitro disease models with a wide range of applications, including evaluating cellular responses to pharmaceutical compounds in drug discovery applications.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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